Naproxen

OTC

Long-acting pain and inflammation medicine.

NSAID with longer half-life.

Generic name

Naproxen

Drug class

NSAIDs

ATC code

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Pregnancy

Ask your doctor

Prescription

Not required

Last updated

2026-01-15

Available forms

TabletCapsuleSuspension

Uses

Arthritis
Period pain
Muscle pain
Migraine

How it works

Blocks pain and swelling chemicals for longer than ibuprofen.

Medical: Inhibits COX-1 and COX-2; longer half-life allows twice-daily dosing.

Common brand names

Aleve, Naprosyn

Naprosyn

Typical dosage

adults250–500 mg twice a day.

childrenUnder medical advice only.

Educational only. Never adjust dosage without medical guidance.

Side effects

Very common

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Common

· Stomach upset
· Heartburn
· Dizziness

Rare

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Serious

· Stomach bleeding
· Kidney issues

Warnings

Take with food
Caution in heart disease
Caution in kidney disease

Interactions

Medicine

Warfarin, ACE inhibitors, Aspirin

Where you usually see it

PharmaciesSports clinicsRheumatology clinics

Timeline

1976
First approved in the US.
1994
Available OTC in the US.

Fun facts

· Longer-acting than ibuprofen — fewer doses per day.

Conditions it treats

Migraine Headache

Related medicines

Compare

See how Naproxen stacks up next to another medicine.

Naproxen vs Ibuprofen Naproxen vs Paracetamol Naproxen vs Aspirin Naproxen vs Diclofenac

Frequently asked

How often do I take it?

Typically twice a day, with food.

Educational use only.This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional before starting, stopping, or changing any medication.