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| Attribute | Sumatriptan | Naproxen |
|---|---|---|
| Simple | Migraine-specific medicine. | Long-acting pain and inflammation medicine. |
| Drug class | Serotonin (5-HT1) receptor agonist. | NSAID with longer half-life. |
| Prescription | Rx only | OTC |
| Uses | Migraine, Cluster headache | Arthritis, Period pain, Muscle pain, Migraine |
| Forms | Tablet, Nasal spray, Injection | Tablet, Capsule, Suspension |
| Adult dosage | 50–100 mg at start of migraine; may repeat once after 2 hours. | 250–500 mg twice a day. |
| Pregnancy | Ask your doctor | Ask your doctor |
| Common side effects | Tingling, Chest tightness, Drowsiness | Stomach upset, Heartburn, Dizziness |